BandIn this stage of WBCmaturation, thenucleus is indented>1/2 the width of thehypothetical roundnucleus. The nucleusis shaped like “C, S,or U”.ETMyeloproliferativeneoplasmsinvolved withmegakaryocyticcell lineCLLclumped chromatin"cracked"appearance.presence of smudgecells. can make analbumin smear. manypatients have noapparent symptoms.AMLCD 33 and CD 13seen in adultsmedium to largemyeloblasts.MPO positiveSBB positiveALLNeutropenia.Lymphoblastscirculating.primarily in youngchildren. May beCNS involvementPVmyeloproliferativeneoplasmsassociated witherythroid cell lineJak2 mutationSmudgeCellThis abnormal WBCmorphology is associatedwith chronic lymphocyticleukemia and are remnantsof cells that lack anyidentifiable cytoplasmicmembrane or nuclearstructure. Adding 22%bovine albumin to the bloodsample prior to making thebloodPromyelocyteIn this stage of WBCmaturation, theproduction of primarygranules begins. Thechromatin is slightlycondensing, and 1-3nucleoli may bevisible.MetamyelocyteIn this stage of WBCmaturation, the nucleus isindented <1/2 the width ofthe hypothetical roundnucleus. Nucleoli areabsent the chromatin iscoarse and clumped.Cytoplasm is pink withmany secondary granules.ToxicGranulationThis toxic changeconsists ofprominent largeblue-black granulesdue to persistentstaining of primarygranules.HodgkinLymphomaReed sternbergcells arepresent. Seenin youngerpopulation,good prognosisMultipleMyelomaa plasma cellcancer marked bymonoclonal IgG,normal anemia withrouleaux and highESR, plus BenceJones light chains.HypersegmentedThis type ofneutrophil has>5 lobes and isassociated withmegaloblasticanemia.BasophilIncreases in thistype of WBC can beseen in type 1hypersensitivityreactions. Thegranules of this cellcontain histamine.BlastThis cell is the earliestrecognizablegranulocyte precursor.The nucleus is round,centrally located withlightly packedchromatin and 2-5nucleoli.MonocyteIncreases in this type ofWBC can be seen intuberculosis, someautoimmune diseases,and irritable bowelsyndrome. Thecytoplasm has a ground-glass appearance andmay contain vacuoles.CML<20% blasts in BMlow LAP leukocytosiswith left shift in WBC.predominant cells areneutrophils andmyelocytes.Philadelphiachromosome.LeukemoidreactionThis is a benign,extreme orexaggerated responseto an infection orstimulus accompaniedby a shift to the left andtoxic changes toneutrophils.EosinophilIncreases inthis type ofWBC can beseen in allergicand parasiticinfections.PMFBone marrowfibrosis teardrops seen onblood smear."Dry Tap"ToxicVacuolizationThis toxic changeresults in colorlessareas in thecytoplasm thatindicate phagocytosisand degranulationhave occurred. Hairy CellLeukemiaThis type of Blymphocyte hasabnormal cytoplasmicprojections that appear“hairy” under themicroscope. TRAPstain used forconfirmation.  MyelocyteIn this stage of WBCmaturation, the productionof secondary granulesbegins, and granulocytescan be differentiated intoneutrophils, basophils, andeosinophils. The cell hasan eccentric nucleus with aprominent perinuclearclearing beside theAuerrodsThese red, stainingneedle-like inclusionsresult from theabnormal fusion ofprimary granules andis often seen in thecytoplasm ofmyeloblasts.BandIn this stage of WBCmaturation, thenucleus is indented>1/2 the width of thehypothetical roundnucleus. The nucleusis shaped like “C, S,or U”.ETMyeloproliferativeneoplasmsinvolved withmegakaryocyticcell lineCLLclumped chromatin"cracked"appearance.presence of smudgecells. can make analbumin smear. manypatients have noapparent symptoms.AMLCD 33 and CD 13seen in adultsmedium to largemyeloblasts.MPO positiveSBB positiveALLNeutropenia.Lymphoblastscirculating.primarily in youngchildren. May beCNS involvementPVmyeloproliferativeneoplasmsassociated witherythroid cell lineJak2 mutationSmudgeCellThis abnormal WBCmorphology is associatedwith chronic lymphocyticleukemia and are remnantsof cells that lack anyidentifiable cytoplasmicmembrane or nuclearstructure. Adding 22%bovine albumin to the bloodsample prior to making thebloodPromyelocyteIn this stage of WBCmaturation, theproduction of primarygranules begins. Thechromatin is slightlycondensing, and 1-3nucleoli may bevisible.MetamyelocyteIn this stage of WBCmaturation, the nucleus isindented <1/2 the width ofthe hypothetical roundnucleus. Nucleoli areabsent the chromatin iscoarse and clumped.Cytoplasm is pink withmany secondary granules.ToxicGranulationThis toxic changeconsists ofprominent largeblue-black granulesdue to persistentstaining of primarygranules.HodgkinLymphomaReed sternbergcells arepresent. Seenin youngerpopulation,good prognosisMultipleMyelomaa plasma cellcancer marked bymonoclonal IgG,normal anemia withrouleaux and highESR, plus BenceJones light chains.HypersegmentedThis type ofneutrophil has>5 lobes and isassociated withmegaloblasticanemia.BasophilIncreases in thistype of WBC can beseen in type 1hypersensitivityreactions. Thegranules of this cellcontain histamine.BlastThis cell is the earliestrecognizablegranulocyte precursor.The nucleus is round,centrally located withlightly packedchromatin and 2-5nucleoli.MonocyteIncreases in this type ofWBC can be seen intuberculosis, someautoimmune diseases,and irritable bowelsyndrome. Thecytoplasm has a ground-glass appearance andmay contain vacuoles.CML<20% blasts in BMlow LAP leukocytosiswith left shift in WBC.predominant cells areneutrophils andmyelocytes.Philadelphiachromosome.LeukemoidreactionThis is a benign,extreme orexaggerated responseto an infection orstimulus accompaniedby a shift to the left andtoxic changes toneutrophils.EosinophilIncreases inthis type ofWBC can beseen in allergicand parasiticinfections.PMFBone marrowfibrosis teardrops seen onblood smear."Dry Tap"ToxicVacuolizationThis toxic changeresults in colorlessareas in thecytoplasm thatindicate phagocytosisand degranulationhave occurred. Hairy CellLeukemiaThis type of Blymphocyte hasabnormal cytoplasmicprojections that appear“hairy” under themicroscope. TRAPstain used forconfirmation.  MyelocyteIn this stage of WBCmaturation, the productionof secondary granulesbegins, and granulocytescan be differentiated intoneutrophils, basophils, andeosinophils. The cell hasan eccentric nucleus with aprominent perinuclearclearing beside theAuerrodsThese red, stainingneedle-like inclusionsresult from theabnormal fusion ofprimary granules andis often seen in thecytoplasm ofmyeloblasts.

WBC Bingo - Call List

(Print) Use this randomly generated list as your call list when playing the game. There is no need to say the BINGO column name. Place some kind of mark (like an X, a checkmark, a dot, tally mark, etc) on each cell as you announce it, to keep track. You can also cut out each item, place them in a bag and pull words from the bag.


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  1. In this stage of WBC maturation, the nucleus is indented >1/2 the width of the hypothetical round nucleus. The nucleus is shaped like “C, S, or U”.
    Band
  2. Myeloproliferative neoplasms involved with megakaryocytic cell line
    ET
  3. clumped chromatin "cracked" appearance. presence of smudge cells. can make an albumin smear. many patients have no apparent symptoms.
    CLL
  4. CD 33 and CD 13 seen in adults medium to large myeloblasts. MPO positive SBB positive
    AML
  5. Neutropenia. Lymphoblasts circulating. primarily in young children. May be CNS involvement
    ALL
  6. myeloproliferative neoplasms associated with erythroid cell line Jak2 mutation
    PV
  7. This abnormal WBC morphology is associated with chronic lymphocytic leukemia and are remnants of cells that lack any identifiable cytoplasmic membrane or nuclear structure. Adding 22% bovine albumin to the blood sample prior to making the blood
    Smudge Cell
  8. In this stage of WBC maturation, the production of primary granules begins. The chromatin is slightly condensing, and 1-3 nucleoli may be visible.
    Promyelocyte
  9. In this stage of WBC maturation, the nucleus is indented <1/2 the width of the hypothetical round nucleus. Nucleoli are absent the chromatin is coarse and clumped. Cytoplasm is pink with many secondary granules.
    Metamyelocyte
  10. This toxic change consists of prominent large blue-black granules due to persistent staining of primary granules.
    Toxic Granulation
  11. Reed sternberg cells are present. Seen in younger population, good prognosis
    Hodgkin Lymphoma
  12. a plasma cell cancer marked by monoclonal IgG, normal anemia with rouleaux and high ESR, plus Bence Jones light chains.
    Multiple Myeloma
  13. This type of neutrophil has >5 lobes and is associated with megaloblastic anemia.
    Hypersegmented
  14. Increases in this type of WBC can be seen in type 1 hypersensitivity reactions. The granules of this cell contain histamine.
    Basophil
  15. This cell is the earliest recognizable granulocyte precursor. The nucleus is round, centrally located with lightly packed chromatin and 2-5 nucleoli.
    Blast
  16. Increases in this type of WBC can be seen in tuberculosis, some autoimmune diseases, and irritable bowel syndrome. The cytoplasm has a ground-glass appearance and may contain vacuoles.
    Monocyte
  17. <20% blasts in BM low LAP leukocytosis with left shift in WBC. predominant cells are neutrophils and myelocytes. Philadelphia chromosome.
    CML
  18. This is a benign, extreme or exaggerated response to an infection or stimulus accompanied by a shift to the left and toxic changes to neutrophils.
    Leukemoid reaction
  19. Increases in this type of WBC can be seen in allergic and parasitic infections.
    Eosinophil
  20. Bone marrow fibrosis tear drops seen on blood smear. "Dry Tap"
    PMF
  21. This toxic change results in colorless areas in the cytoplasm that indicate phagocytosis and degranulation have occurred.
    Toxic Vacuolization
  22. This type of B lymphocyte has abnormal cytoplasmic projections that appear “hairy” under the microscope. TRAP stain used for confirmation.
    Hairy Cell Leukemia
  23. In this stage of WBC maturation, the production of secondary granules begins, and granulocytes can be differentiated into neutrophils, basophils, and eosinophils. The cell has an eccentric nucleus with a prominent perinuclear clearing beside the
    Myelocyte
  24. These red, staining needle-like inclusions result from the abnormal fusion of primary granules and is often seen in the cytoplasm of myeloblasts.
    Auer rods