(Print) Use this randomly generated list as your call list when playing the game. Place some kind of mark (like an X, a checkmark, a dot, tally mark, etc) on each cell as you announce it, to keep track. You can also cut out each item, place them in a bag and pull words from the bag.
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B-WELL DIFFERENTIATED
B-Benign tumors generally resemble their tissue of origin. What term describes this?
O-TP53
O-Which tumor suppressor gene is commonly called the “guardian of the genome”?
I-METASTASIS
I-Malignant cells establish a secondary tumor in the liver after originating in the colon. What is this called?
N-PAPILLOMA
N-A benign epithelial tumor producing finger-like or wart-like projections is called a:
O-RAS
O-Which proto-oncogene family encodes small GTP-binding proteins and is frequently mutated in cancer?
I-BASEMENT MEMBRANE
I-What structure must an epithelial carcinoma breach to become invasive?
N-SARCOMA
N-A malignant neoplasm derived from mesenchymal tissue is called a:
B-BENIGN
B-A tumor is well circumscribed, slow growing, and remains localized. What type of neoplasm is this?
G-STAGE
G-What describes the extent of spread of cancer throughout the body?
N-TERATOMA
N-A tumor containing tissues derived from more than one germ cell layer is called a:
G-DISTANT METASTASIS
G-In TNM, what does M represent?
G-GRADE
G-What describes the degree of differentiation and cytologic aggressiveness of a tumor?
O-PROTO-ONCOGENE
O-A normal gene involved in cell growth that can become cancer-promoting after mutation or inappropriate activation is called a:
O-ONCOGENE
O-What is the activated form of a proto-oncogene that promotes uncontrolled proliferation?
I-ANGIOGENESIS
I-What process allows a growing tumor to develop its own blood supply?
G-PRIMARY TUMOR SIZE
G-In TNM, what does T primarily represent?
I-DESMOPLASIA
I-A carcinoma is surrounded by dense collagenous fibrous tissue produced in response to the tumor. What is this called?
N-CARCINOMA
N-A malignant neoplasm derived from epithelial cells is called a:
B-EXPANSILE GROWTH
B-What type of growth pattern is characteristic of many benign tumors?
G-REGIONAL LYMPH NODE INVOLVEMENT
G-In TNM, what does N represent?
B-ENCAPSULATION
B-What feature may separate a benign tumor from the surrounding normal tissue?
O-RB
O-Which tumor suppressor gene regulates the G1/S cell-cycle checkpoint?
B-METASTASIS
B-What major feature is absent in typical benign neoplasms?
I-INVASION
I-A malignant epithelial tumor penetrates through the basement membrane into the underlying stroma. What process has occurred?
