TD50 pharmacokinetic selectivity second messenger acetylation absorption indirect agonist antagonist decreases ED50 hydroxylation efficacy spare receptors phase I van der waals phase II enzyme inducer hydrogen bond site 2 population increases pharmacodynamic lipophilic ionized down regulation ionic bond reduced hydrophilic adenylyl cyclase stereoisomers affinity cAMP unionized isosteres acceptor site 3 hydroxyl group partial agonist oral individual prodrug hydrolysis targets TD50 pharmacokinetic selectivity second messenger acetylation absorption indirect agonist antagonist decreases ED50 hydroxylation efficacy spare receptors phase I van der waals phase II enzyme inducer hydrogen bond site 2 population increases pharmacodynamic lipophilic ionized down regulation ionic bond reduced hydrophilic adenylyl cyclase stereoisomers affinity cAMP unionized isosteres acceptor site 3 hydroxyl group partial agonist oral individual prodrug hydrolysis targets
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TD50
pharmacokinetic
selectivity
second messenger
acetylation
absorption
indirect agonist
antagonist
decreases
ED50
hydroxylation
efficacy
spare receptors
phase I
van der waals
phase II
enzyme inducer
hydrogen bond
site 2
population
increases
pharmacodynamic
lipophilic
ionized
down regulation
ionic bond
reduced
hydrophilic
adenylyl cyclase
stereoisomers
affinity
cAMP
unionized
isosteres
acceptor
site 3
hydroxyl group
partial agonist
oral
individual
prodrug
hydrolysis
targets