hydrolysis increases efficacy site 2 lipophilic reduced hydroxylation cAMP ionic bond site 3 TD50 acetylation van der waals affinity oral pharmacodynamic phase I isosteres hydroxyl group indirect agonist absorption prodrug ED50 acceptor decreases selectivity phase II enzyme inducer adenylyl cyclase pharmacokinetic hydrophilic hydrogen bond stereoisomers unionized individual targets partial agonist population antagonist second messenger spare receptors down regulation ionized hydrolysis increases efficacy site 2 lipophilic reduced hydroxylation cAMP ionic bond site 3 TD50 acetylation van der waals affinity oral pharmacodynamic phase I isosteres hydroxyl group indirect agonist absorption prodrug ED50 acceptor decreases selectivity phase II enzyme inducer adenylyl cyclase pharmacokinetic hydrophilic hydrogen bond stereoisomers unionized individual targets partial agonist population antagonist second messenger spare receptors down regulation ionized
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hydrolysis
increases
efficacy
site 2
lipophilic
reduced
hydroxylation
cAMP
ionic bond
site 3
TD50
acetylation
van der waals
affinity
oral
pharmacodynamic
phase I
isosteres
hydroxyl group
indirect agonist
absorption
prodrug
ED50
acceptor
decreases
selectivity
phase II
enzyme inducer
adenylyl cyclase
pharmacokinetic
hydrophilic
hydrogen bond
stereoisomers
unionized
individual
targets
partial agonist
population
antagonist
second messenger
spare receptors
down regulation
ionized