partial agonist hydrophilic hydroxylation acceptor adenylyl cyclase van der waals pharmacodynamic oral hydroxyl group prodrug site 2 population down regulation ED50 affinity ionized lipophilic increases reduced phase I pharmacokinetic TD50 hydrolysis targets decreases spare receptors cAMP ionic bond phase II absorption enzyme inducer site 3 second messenger unionized selectivity hydrogen bond efficacy isosteres individual stereoisomers antagonist acetylation indirect agonist partial agonist hydrophilic hydroxylation acceptor adenylyl cyclase van der waals pharmacodynamic oral hydroxyl group prodrug site 2 population down regulation ED50 affinity ionized lipophilic increases reduced phase I pharmacokinetic TD50 hydrolysis targets decreases spare receptors cAMP ionic bond phase II absorption enzyme inducer site 3 second messenger unionized selectivity hydrogen bond efficacy isosteres individual stereoisomers antagonist acetylation indirect agonist
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partial agonist
hydrophilic
hydroxylation
acceptor
adenylyl cyclase
van der waals
pharmacodynamic
oral
hydroxyl group
prodrug
site 2
population
down regulation
ED50
affinity
ionized
lipophilic
increases
reduced
phase I
pharmacokinetic
TD50
hydrolysis
targets
decreases
spare receptors
cAMP
ionic bond
phase II
absorption
enzyme inducer
site 3
second messenger
unionized
selectivity
hydrogen bond
efficacy
isosteres
individual
stereoisomers
antagonist
acetylation
indirect agonist