Crestor 20- 40 mg daily or Lipitor 40-80 mg daily Cyclosporine, diltiazem, colchicine Baseline and then when symptomatic HMG-CoA reductase inhibitor Take with meals, aspirin 325 mg before therapy, avoid hot beverages Baseline, 4-12 weeks after initiation/change in therapy, then routinely every 3-12 mos On therapy for > 12 mos without symptoms Brown urine, fatigue, cramping, unintentional weight loss Myopathy On average, lowers LDL- C levels by 30 to < 50% Heart attack, strenuous exercise, brain injury, hypothyroidism, VitD deficiency Diet, glucocorticoids, nephrotic syndrom, diabetes Niacin Crestor 10 mg daily or Lipitor 10-20 mg daily or Zocor 20-40 mg daily Praluent, Repatha ACS, CAD Fibric acids kidney damage Zetia Nausea, abdominal pain, headache, myalgia Discontinue therapy, vitamin D, Co-enzyme Q-10, nontraditional statin therapy Macrolides, azole antifungals, CCBs On average, lowers LDL- C levels by by ≥ 50% ± DM with 10-yr risk ≥ 7.5%, < 75 yrs with ASCVD, >21 yrs with LDL > 190 mg/dL 40-75 y.o. Crestor 20- 40 mg daily or Lipitor 40-80 mg daily Cyclosporine, diltiazem, colchicine Baseline and then when symptomatic HMG-CoA reductase inhibitor Take with meals, aspirin 325 mg before therapy, avoid hot beverages Baseline, 4-12 weeks after initiation/change in therapy, then routinely every 3-12 mos On therapy for > 12 mos without symptoms Brown urine, fatigue, cramping, unintentional weight loss Myopathy On average, lowers LDL- C levels by 30 to < 50% Heart attack, strenuous exercise, brain injury, hypothyroidism, VitD deficiency Diet, glucocorticoids, nephrotic syndrom, diabetes Niacin Crestor 10 mg daily or Lipitor 10-20 mg daily or Zocor 20-40 mg daily Praluent, Repatha ACS, CAD Fibric acids kidney damage Zetia Nausea, abdominal pain, headache, myalgia Discontinue therapy, vitamin D, Co-enzyme Q-10, nontraditional statin therapy Macrolides, azole antifungals, CCBs On average, lowers LDL- C levels by by ≥ 50% ± DM with 10-yr risk ≥ 7.5%, < 75 yrs with ASCVD, >21 yrs with LDL > 190 mg/dL 40-75 y.o.
(Print)
Crestor 20-40 mg daily or
Lipitor 40-80 mg daily
Cyclosporine, diltiazem, colchicine
Baseline and then when symptomatic
HMG-CoA reductase inhibitor
Take with meals, aspirin 325 mg before therapy, avoid hot beverages
Baseline, 4-12 weeks after initiation/change in therapy, then routinely every 3-12 mos
On therapy for > 12 mos without symptoms
Brown urine, fatigue, cramping, unintentional weight loss
Myopathy
On average, lowers LDL-C levels by 30 to < 50%
Heart attack, strenuous exercise, brain injury, hypothyroidism, VitD deficiency
Diet, glucocorticoids, nephrotic syndrom, diabetes
Niacin
Crestor 10 mg daily or Lipitor 10-20 mg daily or Zocor 20-40 mg daily
Praluent, Repatha
ACS, CAD
Fibric acids
kidney damage
Zetia
Nausea, abdominal pain, headache, myalgia
Discontinue therapy, vitamin D, Co-enzyme Q-10, nontraditional statin therapy
Macrolides, azole antifungals, CCBs
On average, lowers LDL-C levels by by ≥ 50%
± DM with 10-yr risk ≥ 7.5%, < 75 yrs with ASCVD, >21 yrs with LDL > 190 mg/dL
40-75 y.o.
