21hydroxylaseDeficiency ismostcommoncause ofCAH6-7millionNumber ofoogonia at20 weeksgestationherniauterineinguinalesyndromeProbably thediagnosis ofthe Pope inConclave17hydroxylasedeficiencyrare causeof CAH with~ 100 casesreported PGDCan be usedwith IVF toscreen forCAHGranulosacellsA single layerof these cellsis found inprimordialfolliclesMesonephrosDescribedby CasparWolff in1759PrincetonDrG almamater andwhere authorof Middlesexwas on facultyThecaluteincysts10-20% inwomen withgestationaltrophoblasticdisease MRKHCanpresentsimilar toAISPseudogeneCommonmutationin classicCAHACTHIncreasedproduction inpituitary ofCAH babies17 hydroxyprogesteroneLab testused toevaluatefor CAHMullerianductsNamed afterfamousembryologistthese ductsdevelop intofemale reproductivesystem AlfredJostExperimentswith rabbitsexplained roleof local T inmaledevelopmentDHTActive formoftestosteroneHyperpigmentationFrequentlyseem incasesof high levelsof ACTHYupicEskimoHighestcarrierfrequencyof CAHMetanephrousDevelopsintothe renalsystemSomaticcellsIn the absenceof ovarian germcells theseovarian cellsfail to developY containingIntrabdominalgonadNeedsto beremoved1/6Odds offemaleoffspring ofnormal sisterwill be 46 XYAMHTGF-beta familymember thatcausesregressionof mullerianductReteovariiVestigialtubules andLeydig cells inhilarregion of ovary Testosterone19 carbonsteroidconvertedinto DHTCortisolSteroid that isproduced from11-deoxycortisolby 11hydroxylaseSaltwastingSpecific formof classicCAH leadingto neonataldeath1/3Odds thatphenotypicsisters ofaffectedindividualare XYLuteomaHyperplasticmassof luteinized cells1/3 associatedwith maternalhirsutismor virilization MiddlesexNovel byJeffreyEuginidesPrimordialfolliclesThe structurethat formswhen anoogoniummatures.hCGStimTestcan distinguishbetween 5αreductasedeficiency, defectsin testosteronesynthesis andincomplete AIS GermcellsA cell thatdevelopsinto areproductivecellLeydigcellsAndrogenproducingcells intestesCompoundheterozygoteNon-classicforms of 21Hydroxylasedeficiency areusually thisgenetic mixtureOogoniaThesediploid germcells developinto oocytesRenalsystemAnomalies inthis systemoften found inpatients withmulleriananomaliesPara-mesonephrousDescribed byJohannesMuller in1830HermaphroditusIn Greekmythologywas a childof Aphroditeand Hermes.20weeksgestationAge withmaximumnumber offemale germcellsVirilizationLoss of femalebody contours,deepeningvoiceclitoromegalyetcIncompleteAISphenotype ispredominantlyundervirilizedmale withgreat range NomogramUsed tocomparebasal andstim levels of17-OHPGermline stemcellsMice seemto havethese butwe may notCompleteAISfirst describedat Yale whereMorris coinedthe term“testicularfeminization” MeiosisProcess bywhichoogoniabecomeoocytes PlacentaProtectsCAH fetusprior todeliveryInnermedullaryregionContainsovarianblood vessels,lymphaticvessels,and nerves.1-2%enzymeactivityPatients withsimple virilizingmost often havepoint mutationswith ___enzyme activity TruehermaphroditeIndividualwith bothovarian andtesticulartissueOutercortexConsists ofovarianfollicles andstroma inbetween themHOXGenesControl expressionof growth factorsthat induce thestraight wolffianduct to elongateand coil SimplevirilizingNon-lethalform ofclassicCAH11 betahydroxylaseAccountsfor 5-8%of CAHcasesWolffianductsMale ductsnamed afterfamousGermanembryologistand anatomistTGF-betasuperfamilyAMH is amember ofthis super-familySRYRegion of Ychromosomethat leads tomaledevelopmentalpathwayDexamethasoneSteroidtreatment hatedby pregnantwomen at riskfor baby withCAHClassicCAHCan haveboth salt-wasting andsimplevirilizing formsACTHStimtestUsed toscreenfor CAHAdrenalcrisisWhathappens toCAH babyafter deliverySertolicellsCells thatnourishmake germcells intubules5alphareductaseEnzymethatconverts Tto DHTUndervirilizedmalePreferred overmale pseudo-hermaphroditeby DrG6metersLength ofhumanepididymisVirilizedfemalePreferred overfemalepseudo-hermaphroditeby DrG21hydroxylaseDeficiency ismostcommoncause ofCAH6-7millionNumber ofoogonia at20 weeksgestationherniauterineinguinalesyndromeProbably thediagnosis ofthe Pope inConclave17hydroxylasedeficiencyrare causeof CAH with~ 100 casesreported PGDCan be usedwith IVF toscreen forCAHGranulosacellsA single layerof these cellsis found inprimordialfolliclesMesonephrosDescribedby CasparWolff in1759PrincetonDrG almamater andwhere authorof Middlesexwas on facultyThecaluteincysts10-20% inwomen withgestationaltrophoblasticdisease MRKHCanpresentsimilar toAISPseudogeneCommonmutationin classicCAHACTHIncreasedproduction inpituitary ofCAH babies17 hydroxyprogesteroneLab testused toevaluatefor CAHMullerianductsNamed afterfamousembryologistthese ductsdevelop intofemale reproductivesystem AlfredJostExperimentswith rabbitsexplained roleof local T inmaledevelopmentDHTActive formoftestosteroneHyperpigmentationFrequentlyseem incasesof high levelsof ACTHYupicEskimoHighestcarrierfrequencyof CAHMetanephrousDevelopsintothe renalsystemSomaticcellsIn the absenceof ovarian germcells theseovarian cellsfail to developY containingIntrabdominalgonadNeedsto beremoved1/6Odds offemaleoffspring ofnormal sisterwill be 46 XYAMHTGF-beta familymember thatcausesregressionof mullerianductReteovariiVestigialtubules andLeydig cells inhilarregion of ovary Testosterone19 carbonsteroidconvertedinto DHTCortisolSteroid that isproduced from11-deoxycortisolby 11hydroxylaseSaltwastingSpecific formof classicCAH leadingto neonataldeath1/3Odds thatphenotypicsisters ofaffectedindividualare XYLuteomaHyperplasticmassof luteinized cells1/3 associatedwith maternalhirsutismor virilization MiddlesexNovel byJeffreyEuginidesPrimordialfolliclesThe structurethat formswhen anoogoniummatures.hCGStimTestcan distinguishbetween 5αreductasedeficiency, defectsin testosteronesynthesis andincomplete AIS GermcellsA cell thatdevelopsinto areproductivecellLeydigcellsAndrogenproducingcells intestesCompoundheterozygoteNon-classicforms of 21Hydroxylasedeficiency areusually thisgenetic mixtureOogoniaThesediploid germcells developinto oocytesRenalsystemAnomalies inthis systemoften found inpatients withmulleriananomaliesPara-mesonephrousDescribed byJohannesMuller in1830HermaphroditusIn Greekmythologywas a childof Aphroditeand Hermes.20weeksgestationAge withmaximumnumber offemale germcellsVirilizationLoss of femalebody contours,deepeningvoiceclitoromegalyetcIncompleteAISphenotype ispredominantlyundervirilizedmale withgreat range NomogramUsed tocomparebasal andstim levels of17-OHPGermline stemcellsMice seemto havethese butwe may notCompleteAISfirst describedat Yale whereMorris coinedthe term“testicularfeminization” MeiosisProcess bywhichoogoniabecomeoocytes PlacentaProtectsCAH fetusprior todeliveryInnermedullaryregionContainsovarianblood vessels,lymphaticvessels,and nerves.1-2%enzymeactivityPatients withsimple virilizingmost often havepoint mutationswith ___enzyme activity TruehermaphroditeIndividualwith bothovarian andtesticulartissueOutercortexConsists ofovarianfollicles andstroma inbetween themHOXGenesControl expressionof growth factorsthat induce thestraight wolffianduct to elongateand coil SimplevirilizingNon-lethalform ofclassicCAH11 betahydroxylaseAccountsfor 5-8%of CAHcasesWolffianductsMale ductsnamed afterfamousGermanembryologistand anatomistTGF-betasuperfamilyAMH is amember ofthis super-familySRYRegion of Ychromosomethat leads tomaledevelopmentalpathwayDexamethasoneSteroidtreatment hatedby pregnantwomen at riskfor baby withCAHClassicCAHCan haveboth salt-wasting andsimplevirilizing formsACTHStimtestUsed toscreenfor CAHAdrenalcrisisWhathappens toCAH babyafter deliverySertolicellsCells thatnourishmake germcells intubules5alphareductaseEnzymethatconverts Tto DHTUndervirilizedmalePreferred overmale pseudo-hermaphroditeby DrG6metersLength ofhumanepididymisVirilizedfemalePreferred overfemalepseudo-hermaphroditeby DrG

REI DSD Bingo - Call List

(Print) Use this randomly generated list as your call list when playing the game. There is no need to say the BINGO column name. Place some kind of mark (like an X, a checkmark, a dot, tally mark, etc) on each cell as you announce it, to keep track. You can also cut out each item, place them in a bag and pull words from the bag.


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  1. Deficiency is most common cause of CAH
    21 hydroxylase
  2. Number of oogonia at 20 weeks gestation
    6-7 million
  3. Probably the diagnosis of the Pope in Conclave
    hernia uterine inguinale syndrome
  4. rare cause of CAH with ~ 100 cases reported
    17 hydroxylase deficiency
  5. Can be used with IVF to screen for CAH
    PGD
  6. A single layer of these cells is found in primordial follicles
    Granulosa cells
  7. Described by Caspar Wolff in 1759
    Mesonephros
  8. DrG alma mater and where author of Middlesex was on faculty
    Princeton
  9. 10-20% in women with gestational trophoblastic disease
    Theca lutein cysts
  10. Can present similar to AIS
    MRKH
  11. Common mutation in classic CAH
    Pseudogene
  12. Increased production in pituitary of CAH babies
    ACTH
  13. Lab test used to evaluate for CAH
    17 hydroxy progesterone
  14. Named after famous embryologist these ducts develop into female reproductive system
    Mullerian ducts
  15. Experiments with rabbits explained role of local T in male development
    Alfred Jost
  16. Active form of testosterone
    DHT
  17. Frequently seem in cases of high levels of ACTH
    Hyper pigmentation
  18. Highest carrier frequency of CAH
    Yupic Eskimo
  19. Develops into the renal system
    Metanephrous
  20. In the absence of ovarian germ cells these ovarian cells fail to develop
    Somatic cells
  21. Needs to be removed
    Y containing Intrabdominal gonad
  22. Odds of female offspring of normal sister will be 46 XY
    1/6
  23. TGF-beta family member that causes regression of mullerian duct
    AMH
  24. Vestigial tubules and Leydig cells in hilar region of ovary
    Rete ovarii
  25. 19 carbon steroid converted into DHT
    Testosterone
  26. Steroid that is produced from 11-deoxycortisol by 11 hydroxylase
    Cortisol
  27. Specific form of classic CAH leading to neonatal death
    Salt wasting
  28. Odds that phenotypic sisters of affected individual are XY
    1/3
  29. Hyperplastic mass of luteinized cells 1/3 associated with maternal hirsutism or virilization
    Luteoma
  30. Novel by Jeffrey Euginides
    Middlesex
  31. The structure that forms when an oogonium matures.
    Primordial follicles
  32. can distinguish between 5α reductase deficiency, defects in testosterone synthesis and incomplete AIS
    hCG Stim Test
  33. A cell that develops into a reproductive cell
    Germ cells
  34. Androgen producing cells in testes
    Leydig cells
  35. Non-classic forms of 21 Hydroxylase deficiency are usually this genetic mixture
    Compound heterozygote
  36. These diploid germ cells develop into oocytes
    Oogonia
  37. Anomalies in this system often found in patients with mullerian anomalies
    Renal system
  38. Described by Johannes Muller in 1830
    Para-mesonephrous
  39. In Greek mythology was a child of Aphrodite and Hermes.
    Hermaphroditus
  40. Age with maximum number of female germ cells
    20 weeks gestation
  41. Loss of female body contours, deepening voice clitoromegaly etc
    Virilization
  42. phenotype is predominantly undervirilized male with great range
    Incomplete AIS
  43. Used to compare basal and stim levels of 17-OHP
    Nomogram
  44. Mice seem to have these but we may not
    Germ line stem cells
  45. first described at Yale where Morris coined the term “testicular feminization”
    Complete AIS
  46. Process by which oogonia become oocytes
    Meiosis
  47. Protects CAH fetus prior to delivery
    Placenta
  48. Contains ovarian blood vessels, lymphatic vessels, and nerves.
    Inner medullary region
  49. Patients with simple virilizing most often have point mutations with ___ enzyme activity
    1-2% enzyme activity
  50. Individual with both ovarian and testicular tissue
    True hermaphrodite
  51. Consists of ovarian follicles and stroma in between them
    Outer cortex
  52. Control expression of growth factors that induce the straight wolffian duct to elongate and coil
    HOX Genes
  53. Non-lethal form of classic CAH
    Simple virilizing
  54. Accounts for 5-8% of CAH cases
    11 beta hydroxylase
  55. Male ducts named after famous German embryologist and anatomist
    Wolffian ducts
  56. AMH is a member of this super- family
    TGF-beta superfamily
  57. Region of Y chromosome that leads to male developmental pathway
    SRY
  58. Steroid treatment hated by pregnant women at risk for baby with CAH
    Dexamethasone
  59. Can have both salt-wasting and simple virilizing forms
    Classic CAH
  60. Used to screen for CAH
    ACTH Stim test
  61. What happens to CAH baby after delivery
    Adrenal crisis
  62. Cells that nourish make germ cells in tubules
    Sertoli cells
  63. Enzyme that converts T to DHT
    5alpha reductase
  64. Preferred over male pseudo-hermaphrodite by DrG
    Undervirilized male
  65. Length of human epididymis
    6 meters
  66. Preferred over female pseudo-hermaphrodite by DrG
    Virilized female