MeiosisProcess bywhichoogoniabecomeoocytes GermcellsA cell thatdevelopsinto areproductivecellNomogramUsed tocomparebasal andstim levels of17-OHPSRYRegion of Ychromosomethat leads tomaledevelopmentalpathwayCompoundheterozygoteNon-classicforms of 21Hydroxylasedeficiency areusually thisgenetic mixtureLuteomaHyperplasticmassof luteinized cells1/3 associatedwith maternalhirsutismor virilization 11 betahydroxylaseAccountsfor 5-8%of CAHcasesPara-mesonephrousDescribed byJohannesMuller in1830MRKHCanpresentsimilar toAISInnermedullaryregionContainsovarianblood vessels,lymphaticvessels,and nerves.RenalsystemAnomalies inthis systemoften found inpatients withmulleriananomaliesHyperpigmentationFrequentlyseem incasesof high levelsof ACTHMetanephrousDevelopsintothe renalsystemSomaticcellsIn the absenceof ovarian germcells theseovarian cellsfail to develop20weeksgestationAge withmaximumnumber offemale germcellsAMHTGF-beta familymember thatcausesregressionof mullerianductOogoniaThesediploid germcells developinto oocytesMiddlesexNovel byJeffreyEuginidesIncompleteAISphenotype ispredominantlyundervirilizedmale withgreat range OutercortexConsists ofovarianfollicles andstroma inbetween them17 hydroxyprogesteroneLab testused toevaluatefor CAH17hydroxylasedeficiencyrare causeof CAH with~ 100 casesreported AlfredJostExperimentswith rabbitsexplained roleof local T inmaledevelopmentPrincetonDrG almamater andwhere authorof Middlesexwas on faculty1/6Odds offemaleoffspring ofnormal sisterwill be 46 XYHermaphroditusIn Greekmythologywas a childof Aphroditeand Hermes.PlacentaProtectsCAH fetusprior todelivery1-2%enzymeactivityPatients withsimple virilizingmost often havepoint mutationswith ___enzyme activity GranulosacellsA single layerof these cellsis found inprimordialfolliclesThecaluteincysts10-20% inwomen withgestationaltrophoblasticdisease Germline stemcellsMice seemto havethese butwe may not6-7millionNumber ofoogonia at20 weeksgestationTruehermaphroditeIndividualwith bothovarian andtesticulartissueDHTActive formoftestosteroneY containingIntrabdominalgonadNeedsto beremoved6metersLength ofhumanepididymisSimplevirilizingNon-lethalform ofclassicCAHHOXGenesControl expressionof growth factorsthat induce thestraight wolffianduct to elongateand coil MullerianductsNamed afterfamousembryologistthese ductsdevelop intofemale reproductivesystem PseudogeneCommonmutationin classicCAHTestosterone19 carbonsteroidconvertedinto DHTACTHStimtestUsed toscreenfor CAH1/3Odds thatphenotypicsisters ofaffectedindividualare XYCortisolSteroid that isproduced from11-deoxycortisolby 11hydroxylaseWolffianductsMale ductsnamed afterfamousGermanembryologistand anatomistYupicEskimoHighestcarrierfrequencyof CAHVirilizedfemalePreferred overfemalepseudo-hermaphroditeby DrGPrimordialfolliclesThe structurethat formswhen anoogoniummatures.UndervirilizedmalePreferred overmale pseudo-hermaphroditeby DrGMesonephrosDescribedby CasparWolff in175921hydroxylaseDeficiency ismostcommoncause ofCAHAdrenalcrisisWhathappens toCAH babyafter deliveryTGF-betasuperfamilyAMH is amember ofthis super-familyACTHIncreasedproduction inpituitary ofCAH babieshCGStimTestcan distinguishbetween 5αreductasedeficiency, defectsin testosteronesynthesis andincomplete AIS DexamethasoneSteroidtreatment hatedby pregnantwomen at riskfor baby withCAH5alphareductaseEnzymethatconverts Tto DHTVirilizationLoss of femalebody contours,deepeningvoiceclitoromegalyetcClassicCAHCan haveboth salt-wasting andsimplevirilizing formsSaltwastingSpecific formof classicCAH leadingto neonataldeathReteovariiVestigialtubules andLeydig cells inhilarregion of ovary PGDCan be usedwith IVF toscreen forCAHSertolicellsCells thatnourishmake germcells intubulesCompleteAISfirst describedat Yale whereMorris coinedthe term“testicularfeminization” LeydigcellsAndrogenproducingcells intestesherniauterineinguinalesyndromeProbably thediagnosis ofthe Pope inConclaveMeiosisProcess bywhichoogoniabecomeoocytes GermcellsA cell thatdevelopsinto areproductivecellNomogramUsed tocomparebasal andstim levels of17-OHPSRYRegion of Ychromosomethat leads tomaledevelopmentalpathwayCompoundheterozygoteNon-classicforms of 21Hydroxylasedeficiency areusually thisgenetic mixtureLuteomaHyperplasticmassof luteinized cells1/3 associatedwith maternalhirsutismor virilization 11 betahydroxylaseAccountsfor 5-8%of CAHcasesPara-mesonephrousDescribed byJohannesMuller in1830MRKHCanpresentsimilar toAISInnermedullaryregionContainsovarianblood vessels,lymphaticvessels,and nerves.RenalsystemAnomalies inthis systemoften found inpatients withmulleriananomaliesHyperpigmentationFrequentlyseem incasesof high levelsof ACTHMetanephrousDevelopsintothe renalsystemSomaticcellsIn the absenceof ovarian germcells theseovarian cellsfail to develop20weeksgestationAge withmaximumnumber offemale germcellsAMHTGF-beta familymember thatcausesregressionof mullerianductOogoniaThesediploid germcells developinto oocytesMiddlesexNovel byJeffreyEuginidesIncompleteAISphenotype ispredominantlyundervirilizedmale withgreat range OutercortexConsists ofovarianfollicles andstroma inbetween them17 hydroxyprogesteroneLab testused toevaluatefor CAH17hydroxylasedeficiencyrare causeof CAH with~ 100 casesreported AlfredJostExperimentswith rabbitsexplained roleof local T inmaledevelopmentPrincetonDrG almamater andwhere authorof Middlesexwas on faculty1/6Odds offemaleoffspring ofnormal sisterwill be 46 XYHermaphroditusIn Greekmythologywas a childof Aphroditeand Hermes.PlacentaProtectsCAH fetusprior todelivery1-2%enzymeactivityPatients withsimple virilizingmost often havepoint mutationswith ___enzyme activity GranulosacellsA single layerof these cellsis found inprimordialfolliclesThecaluteincysts10-20% inwomen withgestationaltrophoblasticdisease Germline stemcellsMice seemto havethese butwe may not6-7millionNumber ofoogonia at20 weeksgestationTruehermaphroditeIndividualwith bothovarian andtesticulartissueDHTActive formoftestosteroneY containingIntrabdominalgonadNeedsto beremoved6metersLength ofhumanepididymisSimplevirilizingNon-lethalform ofclassicCAHHOXGenesControl expressionof growth factorsthat induce thestraight wolffianduct to elongateand coil MullerianductsNamed afterfamousembryologistthese ductsdevelop intofemale reproductivesystem PseudogeneCommonmutationin classicCAHTestosterone19 carbonsteroidconvertedinto DHTACTHStimtestUsed toscreenfor CAH1/3Odds thatphenotypicsisters ofaffectedindividualare XYCortisolSteroid that isproduced from11-deoxycortisolby 11hydroxylaseWolffianductsMale ductsnamed afterfamousGermanembryologistand anatomistYupicEskimoHighestcarrierfrequencyof CAHVirilizedfemalePreferred overfemalepseudo-hermaphroditeby DrGPrimordialfolliclesThe structurethat formswhen anoogoniummatures.UndervirilizedmalePreferred overmale pseudo-hermaphroditeby DrGMesonephrosDescribedby CasparWolff in175921hydroxylaseDeficiency ismostcommoncause ofCAHAdrenalcrisisWhathappens toCAH babyafter deliveryTGF-betasuperfamilyAMH is amember ofthis super-familyACTHIncreasedproduction inpituitary ofCAH babieshCGStimTestcan distinguishbetween 5αreductasedeficiency, defectsin testosteronesynthesis andincomplete AIS DexamethasoneSteroidtreatment hatedby pregnantwomen at riskfor baby withCAH5alphareductaseEnzymethatconverts Tto DHTVirilizationLoss of femalebody contours,deepeningvoiceclitoromegalyetcClassicCAHCan haveboth salt-wasting andsimplevirilizing formsSaltwastingSpecific formof classicCAH leadingto neonataldeathReteovariiVestigialtubules andLeydig cells inhilarregion of ovary PGDCan be usedwith IVF toscreen forCAHSertolicellsCells thatnourishmake germcells intubulesCompleteAISfirst describedat Yale whereMorris coinedthe term“testicularfeminization” LeydigcellsAndrogenproducingcells intestesherniauterineinguinalesyndromeProbably thediagnosis ofthe Pope inConclave

REI DSD Bingo - Call List

(Print) Use this randomly generated list as your call list when playing the game. There is no need to say the BINGO column name. Place some kind of mark (like an X, a checkmark, a dot, tally mark, etc) on each cell as you announce it, to keep track. You can also cut out each item, place them in a bag and pull words from the bag.


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  1. Process by which oogonia become oocytes
    Meiosis
  2. A cell that develops into a reproductive cell
    Germ cells
  3. Used to compare basal and stim levels of 17-OHP
    Nomogram
  4. Region of Y chromosome that leads to male developmental pathway
    SRY
  5. Non-classic forms of 21 Hydroxylase deficiency are usually this genetic mixture
    Compound heterozygote
  6. Hyperplastic mass of luteinized cells 1/3 associated with maternal hirsutism or virilization
    Luteoma
  7. Accounts for 5-8% of CAH cases
    11 beta hydroxylase
  8. Described by Johannes Muller in 1830
    Para-mesonephrous
  9. Can present similar to AIS
    MRKH
  10. Contains ovarian blood vessels, lymphatic vessels, and nerves.
    Inner medullary region
  11. Anomalies in this system often found in patients with mullerian anomalies
    Renal system
  12. Frequently seem in cases of high levels of ACTH
    Hyper pigmentation
  13. Develops into the renal system
    Metanephrous
  14. In the absence of ovarian germ cells these ovarian cells fail to develop
    Somatic cells
  15. Age with maximum number of female germ cells
    20 weeks gestation
  16. TGF-beta family member that causes regression of mullerian duct
    AMH
  17. These diploid germ cells develop into oocytes
    Oogonia
  18. Novel by Jeffrey Euginides
    Middlesex
  19. phenotype is predominantly undervirilized male with great range
    Incomplete AIS
  20. Consists of ovarian follicles and stroma in between them
    Outer cortex
  21. Lab test used to evaluate for CAH
    17 hydroxy progesterone
  22. rare cause of CAH with ~ 100 cases reported
    17 hydroxylase deficiency
  23. Experiments with rabbits explained role of local T in male development
    Alfred Jost
  24. DrG alma mater and where author of Middlesex was on faculty
    Princeton
  25. Odds of female offspring of normal sister will be 46 XY
    1/6
  26. In Greek mythology was a child of Aphrodite and Hermes.
    Hermaphroditus
  27. Protects CAH fetus prior to delivery
    Placenta
  28. Patients with simple virilizing most often have point mutations with ___ enzyme activity
    1-2% enzyme activity
  29. A single layer of these cells is found in primordial follicles
    Granulosa cells
  30. 10-20% in women with gestational trophoblastic disease
    Theca lutein cysts
  31. Mice seem to have these but we may not
    Germ line stem cells
  32. Number of oogonia at 20 weeks gestation
    6-7 million
  33. Individual with both ovarian and testicular tissue
    True hermaphrodite
  34. Active form of testosterone
    DHT
  35. Needs to be removed
    Y containing Intrabdominal gonad
  36. Length of human epididymis
    6 meters
  37. Non-lethal form of classic CAH
    Simple virilizing
  38. Control expression of growth factors that induce the straight wolffian duct to elongate and coil
    HOX Genes
  39. Named after famous embryologist these ducts develop into female reproductive system
    Mullerian ducts
  40. Common mutation in classic CAH
    Pseudogene
  41. 19 carbon steroid converted into DHT
    Testosterone
  42. Used to screen for CAH
    ACTH Stim test
  43. Odds that phenotypic sisters of affected individual are XY
    1/3
  44. Steroid that is produced from 11-deoxycortisol by 11 hydroxylase
    Cortisol
  45. Male ducts named after famous German embryologist and anatomist
    Wolffian ducts
  46. Highest carrier frequency of CAH
    Yupic Eskimo
  47. Preferred over female pseudo-hermaphrodite by DrG
    Virilized female
  48. The structure that forms when an oogonium matures.
    Primordial follicles
  49. Preferred over male pseudo-hermaphrodite by DrG
    Undervirilized male
  50. Described by Caspar Wolff in 1759
    Mesonephros
  51. Deficiency is most common cause of CAH
    21 hydroxylase
  52. What happens to CAH baby after delivery
    Adrenal crisis
  53. AMH is a member of this super- family
    TGF-beta superfamily
  54. Increased production in pituitary of CAH babies
    ACTH
  55. can distinguish between 5α reductase deficiency, defects in testosterone synthesis and incomplete AIS
    hCG Stim Test
  56. Steroid treatment hated by pregnant women at risk for baby with CAH
    Dexamethasone
  57. Enzyme that converts T to DHT
    5alpha reductase
  58. Loss of female body contours, deepening voice clitoromegaly etc
    Virilization
  59. Can have both salt-wasting and simple virilizing forms
    Classic CAH
  60. Specific form of classic CAH leading to neonatal death
    Salt wasting
  61. Vestigial tubules and Leydig cells in hilar region of ovary
    Rete ovarii
  62. Can be used with IVF to screen for CAH
    PGD
  63. Cells that nourish make germ cells in tubules
    Sertoli cells
  64. first described at Yale where Morris coined the term “testicular feminization”
    Complete AIS
  65. Androgen producing cells in testes
    Leydig cells
  66. Probably the diagnosis of the Pope in Conclave
    hernia uterine inguinale syndrome