(Print) Use this randomly generated list as your call list when playing the game. There is no need to say the BINGO column name. Place some kind of mark (like an X, a checkmark, a dot, tally mark, etc) on each cell as you announce it, to keep track. You can also cut out each item, place them in a bag and pull words from the bag.
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Deficiency is most common cause of CAH
21 hydroxylase
Hyperplastic
mass
of luteinized cells
1/3 associated
with maternal
hirsutism
or virilization
Luteoma
Lab test used to evaluate for CAH
17 hydroxy
progesterone
Experiments with rabbits explained role of local T in male development
Alfred Jost
Male ducts named after famous
German embryologist and anatomist
Wolffian ducts
A cell that develops into a reproductive cell
Germ cells
Common mutation in classic CAH
Pseudogene
Loss of female
body contours, deepening
voice
clitoromegaly etc
Virilization
Steroid treatment hated by pregnant women at risk for baby with CAH
Dexamethasone
Active form of testosterone
DHT
What happens to CAH baby after delivery
Adrenal crisis
19 carbon
steroid
converted into DHT
Testosterone
Mice seem to have these but we may not
Germ line stem cells
Cells that nourish make germ cells in tubules
Sertoli cells
Number of oogonia at 20 weeks gestation
6-7 million
Described by Johannes Muller in 1830
Para-mesonephrous
Individual with both ovarian and testicular tissue
True hermaphrodite
Probably the diagnosis of the Pope in Conclave
hernia uterine inguinale syndrome
Odds of female offspring of normal sister will be 46 XY
1/6
Consists of ovarian follicles and stroma in between them
Outer cortex
TGF-beta family
member that
causes
regression
of mullerian
duct
AMH
Vestigial tubules and Leydig cells in hilar
region of ovary
Rete ovarii
Process by
which oogonia
become oocytes
Meiosis
AMH is a member of this super-
family
TGF-beta superfamily
Needs to be removed
Y containing Intrabdominal gonad
Frequently seem in cases
of high levels of ACTH
Hyper
pigmentation
Can present similar to AIS
MRKH
In the absence of ovarian germ
cells these
ovarian cells
fail to develop
Somatic cells
Can have both salt-wasting and simple virilizing forms
Classic CAH
Preferred over
female pseudo-hermaphrodite
by DrG
Virilized female
Patients with
simple virilizing
most often have
point mutations
with ___ enzyme activity
1-2% enzyme activity
can distinguish between 5α reductase deficiency, defects in testosterone synthesis and incomplete AIS
hCG Stim Test
Accounts for 5-8% of CAH cases
11 beta hydroxylase
In Greek
mythology was a child of Aphrodite and Hermes.
Hermaphroditus
DrG alma mater and where author of Middlesex was on faculty
Princeton
Increased production in pituitary of CAH babies
ACTH
first described at Yale where Morris coined the term “testicular feminization”
Complete AIS
Length of human epididymis
6 meters
Specific form
of classic
CAH leading
to neonatal
death
Salt wasting
Non-lethal form of classic CAH
Simple virilizing
Novel by Jeffrey Euginides
Middlesex
Steroid that is produced from 11-deoxycortisol by 11 hydroxylase
Cortisol
Androgen producing cells in testes
Leydig cells
rare cause of CAH with ~ 100 cases reported
17 hydroxylase deficiency
A single layer of these cells is found in primordial follicles
Granulosa cells
Odds that phenotypic
sisters of
affected individual
are XY
1/3
Named after famous embryologist
these ducts
develop into
female reproductive system
Mullerian ducts
Can be used with IVF to screen for CAH
PGD
10-20% in women with gestational trophoblastic disease
Theca lutein cysts
The structure
that forms
when an oogonium matures.
Primordial follicles
Control expression
of growth factors
that induce the
straight wolffian
duct to elongate and coil
HOX Genes
Enzyme that converts T to DHT
5alpha reductase
Used to screen for CAH
ACTH Stim test
Described by Caspar Wolff in 1759
Mesonephros
Contains ovarian
blood vessels,
lymphatic vessels,
and nerves.
Inner medullary region
Protects CAH fetus prior to delivery
Placenta
Highest carrier frequency of CAH
Yupic Eskimo
Anomalies in this system often found in patients with mullerian anomalies
Renal system
Develops into
the renal system
Metanephrous
Preferred over
male pseudo-hermaphrodite
by DrG
Undervirilized male
These diploid germ cells develop into oocytes
Oogonia
Used to compare basal and stim levels of 17-OHP
Nomogram
Age with maximum
number of
female germ cells
20 weeks gestation
Region of Y chromosome that leads to male developmental pathway
SRY
Non-classic forms of 21 Hydroxylase deficiency are usually this genetic mixture
Compound heterozygote
phenotype is predominantly undervirilized male with great range
Incomplete AIS
