This bingo card has a free space and 28 words: Caused by a mutation in the LMNA gene on chromosome 1, Progerin causes the nuclear envelope to become unstable and disrupt nuclear shape, Progerin disrupts the cell’s nucleus, causing premature cell aging, The mutation leads to production of an abnormal protein called progerin, LMNA gene produces lamin A, a protein essential for maintaining the structure of the cell nucleus, A rare genetic disorder causing rapid aging in children, First described in the late 19th century, named after Hutchinson and Gilford, Affects about 1 in 4 million newborns worldwide, Children appear normal at birth but show signs of aging within the first two years and live up until their teen years., Hair loss (alopecia) and aged-looking skin, Joint stiffness and loss of fat under the skin, Intellectual development and motor skills remain normal, Growth failure: children grow slower and weigh less than peers, Characteristic facial appearance: prominent eyes, thin nose with beaked tip, small chin, protruding ears, Severe arteriosclerosis (hardening of arteries) begins in childhood, Increased risk of heart attack and stroke at a young age, Major cause of death in progeria patients, usually in their teens, This leads to DNA damage and impaired cell division, Cells age faster and die prematurely, especially in connective tissues and blood vessels which explains skin aging, joint problems, and cardiovascular disease, Cellular aging accelerated, mimicking aspects of normal aging at molecular level, Discovery of the LMNA mutation in 2003 was a major milestone, Development of farnesyltransferase inhibitors (FTIs) to block progerin’s harmful effects have shown promise in clinical trials by improving some symptoms, There is no cure yet, but doctors can help with symptoms, Medicines can help protect the heart and improve quality of life, Doctors also suggest healthy food and exercise for children with progeria, Clinical trials show improved cardiovascular health and lifespan extension, Research continues to focus on slowing disease progression and improving life quality and Emerging gene editing approaches like CRISPR hold future potential.
DNA Structure and Function | Organelles and Heredity BINGO | Traits and Reproduction | Cell Bingo | Category 1
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