The mutationleads toproduction ofan abnormalprotein calledprogerin First describedin the late 19thcentury, namedafterHutchinson andGilfordDevelopment offarnesyltransferaseinhibitors (FTIs) toblock progerin’sharmful effects haveshown promise inclinical trials byimproving somesymptomsLMNA geneproduces lamin A,a protein essentialfor maintaining thestructure of thecell nucleus There is nocure yet, butdoctors canhelp withsymptomsIncreasedrisk of heartattack andstroke at ayoung ageDiscovery ofthe LMNAmutation in2003 was amajor milestoneSeverearteriosclerosis(hardening ofarteries) beginsin childhoodA rare geneticdisordercausing rapidaging inchildrenThis leads toDNAdamage andimpaired celldivisionResearchcontinues to focuson slowingdiseaseprogression andimproving lifequalityCellular agingaccelerated,mimickingaspects ofnormal aging atmolecular levelDoctors alsosuggest healthyfood andexercise forchildren withprogeriaMedicines canhelp protectthe heart andimprovequality of lifeProgerin causesthe nuclearenvelope tobecome unstableand disruptnuclear shape Characteristicfacial appearance:prominent eyes,thin nose withbeaked tip, smallchin, protrudingearsChildren appearnormal at birth butshow signs ofaging within thefirst two years andlive up until theirteen years.Caused by amutation in theLMNA gene onchromosome 1Emerging geneeditingapproaches likeCRISPR holdfuture potentialMajor cause ofdeath inprogeriapatients,usually in theirteensIntellectualdevelopmentand motorskills remainnormalCells age faster anddie prematurely,especially inconnective tissues andblood vessels whichexplains skin aging,joint problems, andcardiovascular diseaseJointstiffness andloss of fatunder theskinProgerindisrupts thecell’s nucleus,causingpremature cellaging Clinical trialsshow improvedcardiovascularhealth andlifespanextensionGrowth failure:children growslower andweigh lessthan peersHair loss(alopecia)and aged-looking skinAffects about1 in 4 millionnewbornsworldwideThe mutationleads toproduction ofan abnormalprotein calledprogerin First describedin the late 19thcentury, namedafterHutchinson andGilfordDevelopment offarnesyltransferaseinhibitors (FTIs) toblock progerin’sharmful effects haveshown promise inclinical trials byimproving somesymptomsLMNA geneproduces lamin A,a protein essentialfor maintaining thestructure of thecell nucleus There is nocure yet, butdoctors canhelp withsymptomsIncreasedrisk of heartattack andstroke at ayoung ageDiscovery ofthe LMNAmutation in2003 was amajor milestoneSeverearteriosclerosis(hardening ofarteries) beginsin childhoodA rare geneticdisordercausing rapidaging inchildrenThis leads toDNAdamage andimpaired celldivisionResearchcontinues to focuson slowingdiseaseprogression andimproving lifequalityCellular agingaccelerated,mimickingaspects ofnormal aging atmolecular levelDoctors alsosuggest healthyfood andexercise forchildren withprogeriaMedicines canhelp protectthe heart andimprovequality of lifeProgerin causesthe nuclearenvelope tobecome unstableand disruptnuclear shape Characteristicfacial appearance:prominent eyes,thin nose withbeaked tip, smallchin, protrudingearsChildren appearnormal at birth butshow signs ofaging within thefirst two years andlive up until theirteen years.Caused by amutation in theLMNA gene onchromosome 1Emerging geneeditingapproaches likeCRISPR holdfuture potentialMajor cause ofdeath inprogeriapatients,usually in theirteensIntellectualdevelopmentand motorskills remainnormalCells age faster anddie prematurely,especially inconnective tissues andblood vessels whichexplains skin aging,joint problems, andcardiovascular diseaseJointstiffness andloss of fatunder theskinProgerindisrupts thecell’s nucleus,causingpremature cellaging Clinical trialsshow improvedcardiovascularhealth andlifespanextensionGrowth failure:children growslower andweigh lessthan peersHair loss(alopecia)and aged-looking skinAffects about1 in 4 millionnewbornsworldwide

Progeria Bingo - Call List

(Print) Use this randomly generated list as your call list when playing the game. There is no need to say the BINGO column name. Place some kind of mark (like an X, a checkmark, a dot, tally mark, etc) on each cell as you announce it, to keep track. You can also cut out each item, place them in a bag and pull words from the bag.


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  1. The mutation leads to production of an abnormal protein called progerin
  2. First described in the late 19th century, named after Hutchinson and Gilford
  3. Development of farnesyltransferase inhibitors (FTIs) to block progerin’s harmful effects have shown promise in clinical trials by improving some symptoms
  4. LMNA gene produces lamin A, a protein essential for maintaining the structure of the cell nucleus
  5. There is no cure yet, but doctors can help with symptoms
  6. Increased risk of heart attack and stroke at a young age
  7. Discovery of the LMNA mutation in 2003 was a major milestone
  8. Severe arteriosclerosis (hardening of arteries) begins in childhood
  9. A rare genetic disorder causing rapid aging in children
  10. This leads to DNA damage and impaired cell division
  11. Research continues to focus on slowing disease progression and improving life quality
  12. Cellular aging accelerated, mimicking aspects of normal aging at molecular level
  13. Doctors also suggest healthy food and exercise for children with progeria
  14. Medicines can help protect the heart and improve quality of life
  15. Progerin causes the nuclear envelope to become unstable and disrupt nuclear shape
  16. Characteristic facial appearance: prominent eyes, thin nose with beaked tip, small chin, protruding ears
  17. Children appear normal at birth but show signs of aging within the first two years and live up until their teen years.
  18. Caused by a mutation in the LMNA gene on chromosome 1
  19. Emerging gene editing approaches like CRISPR hold future potential
  20. Major cause of death in progeria patients, usually in their teens
  21. Intellectual development and motor skills remain normal
  22. Cells age faster and die prematurely, especially in connective tissues and blood vessels which explains skin aging, joint problems, and cardiovascular disease
  23. Joint stiffness and loss of fat under the skin
  24. Progerin disrupts the cell’s nucleus, causing premature cell aging
  25. Clinical trials show improved cardiovascular health and lifespan extension
  26. Growth failure: children grow slower and weigh less than peers
  27. Hair loss (alopecia) and aged-looking skin
  28. Affects about 1 in 4 million newborns worldwide