Progeria Bingo - Call List

(Print) Use this randomly generated list as your call list when playing the game. There is no need to say the BINGO column name. Place some kind of mark (like an X, a checkmark, a dot, tally mark, etc) on each cell as you announce it, to keep track. You can also cut out each item, place them in a bag and pull words from the bag.

1. Affects about 1 in 4 million newborns worldwide
2. Medicines can help protect the heart and improve quality of life
3. Doctors also suggest healthy food and exercise for children with progeria
4. Hair loss (alopecia) and aged-looking skin
5. LMNA gene produces lamin A, a protein essential for maintaining the structure of the cell nucleus
6. This leads to DNA damage and impaired cell division
7. Discovery of the LMNA mutation in 2003 was a major milestone
8. Caused by a mutation in the LMNA gene on chromosome 1
9. Clinical trials show improved cardiovascular health and lifespan extension
10. Emerging gene editing approaches like CRISPR hold future potential
11. The mutation leads to production of an abnormal protein called progerin
12. Cells age faster and die prematurely, especially in connective tissues and blood vessels which explains skin aging, joint problems, and cardiovascular disease
13. Increased risk of heart attack and stroke at a young age
14. Joint stiffness and loss of fat under the skin
15. Children appear normal at birth but show signs of aging within the first two years and live up until their teen years.
16. Severe arteriosclerosis (hardening of arteries) begins in childhood
17. Growth failure: children grow slower and weigh less than peers
18. There is no cure yet, but doctors can help with symptoms
19. A rare genetic disorder causing rapid aging in children
20. Intellectual development and motor skills remain normal
21. Research continues to focus on slowing disease progression and improving life quality
22. Progerin disrupts the cell’s nucleus, causing premature cell aging
23. Characteristic facial appearance: prominent eyes, thin nose with beaked tip, small chin, protruding ears
24. First described in the late 19th century, named after Hutchinson and Gilford
25. Cellular aging accelerated, mimicking aspects of normal aging at molecular level
26. Development of farnesyltransferase inhibitors (FTIs) to block progerin’s harmful effects have shown promise in clinical trials by improving some symptoms
27. Progerin causes the nuclear envelope to become unstable and disrupt nuclear shape
28. Major cause of death in progeria patients, usually in their teens