Progerin causesthe nuclearenvelope tobecome unstableand disruptnuclear shape Severearteriosclerosis(hardening ofarteries) beginsin childhoodThe mutationleads toproduction ofan abnormalprotein calledprogerin Children appearnormal at birth butshow signs ofaging within thefirst two years andlive up until theirteen years.Increasedrisk of heartattack andstroke at ayoung ageDevelopment offarnesyltransferaseinhibitors (FTIs) toblock progerin’sharmful effects haveshown promise inclinical trials byimproving somesymptomsAffects about1 in 4 millionnewbornsworldwideMedicines canhelp protectthe heart andimprovequality of lifeEmerging geneeditingapproaches likeCRISPR holdfuture potentialFirst describedin the late 19thcentury, namedafterHutchinson andGilfordLMNA geneproduces lamin A,a protein essentialfor maintaining thestructure of thecell nucleus Clinical trialsshow improvedcardiovascularhealth andlifespanextensionCells age faster anddie prematurely,especially inconnective tissues andblood vessels whichexplains skin aging,joint problems, andcardiovascular diseaseA rare geneticdisordercausing rapidaging inchildrenProgerindisrupts thecell’s nucleus,causingpremature cellaging Hair loss(alopecia)and aged-looking skinGrowth failure:children growslower andweigh lessthan peersThis leads toDNAdamage andimpaired celldivisionIntellectualdevelopmentand motorskills remainnormalCaused by amutation in theLMNA gene onchromosome 1Characteristicfacial appearance:prominent eyes,thin nose withbeaked tip, smallchin, protrudingearsThere is nocure yet, butdoctors canhelp withsymptomsDiscovery ofthe LMNAmutation in2003 was amajor milestoneResearchcontinues to focuson slowingdiseaseprogression andimproving lifequalityDoctors alsosuggest healthyfood andexercise forchildren withprogeriaCellular agingaccelerated,mimickingaspects ofnormal aging atmolecular levelMajor cause ofdeath inprogeriapatients,usually in theirteensJointstiffness andloss of fatunder theskinProgerin causesthe nuclearenvelope tobecome unstableand disruptnuclear shape Severearteriosclerosis(hardening ofarteries) beginsin childhoodThe mutationleads toproduction ofan abnormalprotein calledprogerin Children appearnormal at birth butshow signs ofaging within thefirst two years andlive up until theirteen years.Increasedrisk of heartattack andstroke at ayoung ageDevelopment offarnesyltransferaseinhibitors (FTIs) toblock progerin’sharmful effects haveshown promise inclinical trials byimproving somesymptomsAffects about1 in 4 millionnewbornsworldwideMedicines canhelp protectthe heart andimprovequality of lifeEmerging geneeditingapproaches likeCRISPR holdfuture potentialFirst describedin the late 19thcentury, namedafterHutchinson andGilfordLMNA geneproduces lamin A,a protein essentialfor maintaining thestructure of thecell nucleus Clinical trialsshow improvedcardiovascularhealth andlifespanextensionCells age faster anddie prematurely,especially inconnective tissues andblood vessels whichexplains skin aging,joint problems, andcardiovascular diseaseA rare geneticdisordercausing rapidaging inchildrenProgerindisrupts thecell’s nucleus,causingpremature cellaging Hair loss(alopecia)and aged-looking skinGrowth failure:children growslower andweigh lessthan peersThis leads toDNAdamage andimpaired celldivisionIntellectualdevelopmentand motorskills remainnormalCaused by amutation in theLMNA gene onchromosome 1Characteristicfacial appearance:prominent eyes,thin nose withbeaked tip, smallchin, protrudingearsThere is nocure yet, butdoctors canhelp withsymptomsDiscovery ofthe LMNAmutation in2003 was amajor milestoneResearchcontinues to focuson slowingdiseaseprogression andimproving lifequalityDoctors alsosuggest healthyfood andexercise forchildren withprogeriaCellular agingaccelerated,mimickingaspects ofnormal aging atmolecular levelMajor cause ofdeath inprogeriapatients,usually in theirteensJointstiffness andloss of fatunder theskin

Progeria Bingo - Call List

(Print) Use this randomly generated list as your call list when playing the game. There is no need to say the BINGO column name. Place some kind of mark (like an X, a checkmark, a dot, tally mark, etc) on each cell as you announce it, to keep track. You can also cut out each item, place them in a bag and pull words from the bag.


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  1. Progerin causes the nuclear envelope to become unstable and disrupt nuclear shape
  2. Severe arteriosclerosis (hardening of arteries) begins in childhood
  3. The mutation leads to production of an abnormal protein called progerin
  4. Children appear normal at birth but show signs of aging within the first two years and live up until their teen years.
  5. Increased risk of heart attack and stroke at a young age
  6. Development of farnesyltransferase inhibitors (FTIs) to block progerin’s harmful effects have shown promise in clinical trials by improving some symptoms
  7. Affects about 1 in 4 million newborns worldwide
  8. Medicines can help protect the heart and improve quality of life
  9. Emerging gene editing approaches like CRISPR hold future potential
  10. First described in the late 19th century, named after Hutchinson and Gilford
  11. LMNA gene produces lamin A, a protein essential for maintaining the structure of the cell nucleus
  12. Clinical trials show improved cardiovascular health and lifespan extension
  13. Cells age faster and die prematurely, especially in connective tissues and blood vessels which explains skin aging, joint problems, and cardiovascular disease
  14. A rare genetic disorder causing rapid aging in children
  15. Progerin disrupts the cell’s nucleus, causing premature cell aging
  16. Hair loss (alopecia) and aged-looking skin
  17. Growth failure: children grow slower and weigh less than peers
  18. This leads to DNA damage and impaired cell division
  19. Intellectual development and motor skills remain normal
  20. Caused by a mutation in the LMNA gene on chromosome 1
  21. Characteristic facial appearance: prominent eyes, thin nose with beaked tip, small chin, protruding ears
  22. There is no cure yet, but doctors can help with symptoms
  23. Discovery of the LMNA mutation in 2003 was a major milestone
  24. Research continues to focus on slowing disease progression and improving life quality
  25. Doctors also suggest healthy food and exercise for children with progeria
  26. Cellular aging accelerated, mimicking aspects of normal aging at molecular level
  27. Major cause of death in progeria patients, usually in their teens
  28. Joint stiffness and loss of fat under the skin