This bingo card has a free space and 119 words: 1, 6, 11, 16, 21, 2, 7, 12, 17, 22, 3, 8, 18, 23, 4, 9, 14, 19, 24, 5, 10, 15, 20, 25, B1, A tumor is well circumscribed, slow growing, and remains localized. What type of neoplasm is this?, Answer: BENIGN, B2, What feature may separate a benign tumor from the surrounding normal tissue?, Answer: ENCAPSULATION, B3, Benign tumors generally resemble their tissue of origin. What term describes this?, Answer: WELL DIFFERENTIATED, B4, What type of growth pattern is characteristic of many benign tumors?, Answer: EXPANSILE GROWTH, B5, What major feature is absent in typical benign neoplasms?, Answer: METASTASIS / NO METASTASIS, ⸻, 🟥 I — INVASION & MALIGNANCY, I1, A malignant epithelial tumor penetrates through the basement membrane into the underlying stroma. What process has occurred?, Answer: INVASION, I2, Malignant cells establish a secondary tumor in the liver after originating in the colon. What is this called?, Answer: METASTASIS, I3, What structure must an epithelial carcinoma breach to become invasive?, Answer: BASEMENT MEMBRANE, I4, A carcinoma is surrounded by dense collagenous fibrous tissue produced in response to the tumor. What is this called?, Answer: DESMOPLASIA, I5, What process allows a growing tumor to develop its own blood supply?, Answer: ANGIOGENESIS, ⸻, 🟨 N — NOMENCLATURE, N1, A malignant neoplasm derived from epithelial cells is called a:, Answer: CARCINOMA, N2, A malignant neoplasm derived from mesenchymal tissue is called a:, Answer: SARCOMA, N3, A benign glandular epithelial neoplasm is called an:, Answer: ADENOMA, N4, A benign epithelial tumor producing finger-like or wart-like projections is called a:, Answer: PAPILLOMA, N5, A tumor containing tissues derived from more than one germ cell layer is called a:, Answer: TERATOMA, 🔥 Nomenclature Challenge, Ask:, Is every tumor ending in “-oma” benign?, Answer: NO., Examples of malignant tumors ending in “-oma” include:, * Melanoma, * Lymphoma, * Seminoma, * Mesothelioma, ⸻, 🟩 G — GRADING & STAGING / TNM, G1, What describes the degree of differentiation and cytologic aggressiveness of a tumor?, Answer: GRADE, G2, What describes the extent of spread of cancer throughout the body?, Answer: STAGE, G3, In TNM, what does T primarily represent?, Answer: PRIMARY TUMOR, G4, In TNM, what does N represent?, Answer: REGIONAL LYMPH NODE INVOLVEMENT, G5, In TNM, what does M represent?, Answer: DISTANT METASTASIS, 🔥 HOTS Question, A patient has a 3-cm carcinoma with regional lymph-node involvement but no distant metastasis., Which TNM component is represented by the lymph-node involvement?, Answer: N, ⸻, 🟪 O — ONCOGENESIS & MOLECULAR ALTERATIONS, O1, A normal gene involved in cell growth that can become cancer-promoting after mutation or inappropriate activation is called a:, Answer: PROTO-ONCOGENE, O2, What is the activated form of a proto-oncogene that promotes uncontrolled proliferation?, Answer: ONCOGENE, O3, Which tumor suppressor gene is commonly called the “guardian of the genome”?, Answer: TP53, O4, Which proto-oncogene family encodes small GTP-binding proteins and is frequently mutated in cancer? Answer: RAS, O5, Which tumor suppressor gene regulates the G1/S cell-cycle checkpoint? and Answer: RB.
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