This bingo card has a free space and 86 words: A tumor is well circumscribed, slow growing, and remains localized. What type of neoplasm is this?, What feature may separate a benign tumor from the surrounding normal tissue?, Benign tumors generally resemble their tissue of origin. What term describes this?, What type of growth pattern is characteristic of many benign tumors?, What major feature is absent in typical benign neoplasms?, ⸻, 🟥 I — INVASION & MALIGNANCY, I1, A malignant epithelial tumor penetrates through the basement membrane into the underlying stroma. What process has occurred?, Answer: INVASION, I2, Malignant cells establish a secondary tumor in the liver after originating in the colon. What is this called?, Answer: METASTASIS, I3, What structure must an epithelial carcinoma breach to become invasive?, Answer: BASEMENT MEMBRANE, I4, A carcinoma is surrounded by dense collagenous fibrous tissue produced in response to the tumor. What is this called?, Answer: DESMOPLASIA, I5, What process allows a growing tumor to develop its own blood supply?, Answer: ANGIOGENESIS, ⸻, 🟨 N — NOMENCLATURE, N1, A malignant neoplasm derived from epithelial cells is called a:, Answer: CARCINOMA, N2, A malignant neoplasm derived from mesenchymal tissue is called a:, Answer: SARCOMA, N3, A benign glandular epithelial neoplasm is called an:, Answer: ADENOMA, N4, A benign epithelial tumor producing finger-like or wart-like projections is called a:, Answer: PAPILLOMA, N5, A tumor containing tissues derived from more than one germ cell layer is called a:, Answer: TERATOMA, 🔥 Nomenclature Challenge, Ask:, Is every tumor ending in “-oma” benign?, Answer: NO., Examples of malignant tumors ending in “-oma” include:, * Melanoma, * Lymphoma, * Seminoma, * Mesothelioma, ⸻, 🟩 G — GRADING & STAGING / TNM, G1, What describes the degree of differentiation and cytologic aggressiveness of a tumor?, Answer: GRADE, G2, What describes the extent of spread of cancer throughout the body?, Answer: STAGE, G3, In TNM, what does T primarily represent?, Answer: PRIMARY TUMOR, G4, In TNM, what does N represent?, Answer: REGIONAL LYMPH NODE INVOLVEMENT, G5, In TNM, what does M represent?, Answer: DISTANT METASTASIS, 🔥 HOTS Question, A patient has a 3-cm carcinoma with regional lymph-node involvement but no distant metastasis., Which TNM component is represented by the lymph-node involvement?, Answer: N, ⸻, 🟪 O — ONCOGENESIS & MOLECULAR ALTERATIONS, O1, A normal gene involved in cell growth that can become cancer-promoting after mutation or inappropriate activation is called a:, Answer: PROTO-ONCOGENE, O2, What is the activated form of a proto-oncogene that promotes uncontrolled proliferation?, Answer: ONCOGENE, O3, Which tumor suppressor gene is commonly called the “guardian of the genome”?, Answer: TP53, O4, Which proto-oncogene family encodes small GTP-binding proteins and is frequently mutated in cancer?, Answer: RAS, O5, Which tumor suppressor gene regulates the G1/S cell-cycle checkpoint? and Answer: RB.
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