This bingo card has 13 images and 15 words: Panels B and C, The relative abundance of each type of splicing error present, there are more men than women in the control group (equal in experimental group) - how close/ far the people are from HD threshold and its effects -ages of the subjects with biopsy was taken, prevents non-specific Ab binding as the it covers unoccupied space that would otherwise attract Ab, Increased CAG repeats, more affect of Branaplam, with no mHHT, relatively no effect of treatment, as expected, Any colored point, outside of the inside dashed lines are significant. Red = more, Blue = less, Free!, It is the solvent used with Branaplam, so using DMSO alone is the negative control, The increased number of exons, creates a frameshift, resulting in reduction of mHTT as the sequence does not create poly-Q protein sequence that is responsible for HD side effects, Panel E, Typically, HD medications lower HTT levels to reduce mHTT toxicity, but Branaplam did not increase cell toxicity in fibroblasts and iPSC cells, There is no impact of HD on cell differentiation, so the study will not focus on the middle stages of Figure 1a, Trying to verify that the system the authors propose is going to work, Promote inclusion of exon 7 in the SMN2 transcript as an intervention for SMA (spinal muscular atrophy) and It's oral, while others are injected.
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