There is no impactof HD on celldifferentiation, sothe study will notfocus on themiddle stages ofFigure 1a prevents non-specific Ab bindingas the it coversunoccupied spacethat wouldotherwise attractAbTypically, HDmedications lowerHTT levels to reducemHTT toxicity, butBranaplam did notincrease cell toxicityin fibroblasts andiPSC cells Promote inclusionof exon 7 in theSMN2 transcriptas an interventionfor SMA (spinalmuscular atrophy) PanelsB andCThe increased numberof exons, creates aframeshift, resulting inreduction of mHTT asthe sequence does notcreate poly-Q proteinsequence that isresponsible for HDside effects there are more men thanwomen in the controlgroup (equal inexperimental group)- how close/ far thepeople are from HDthreshold and its effects-ages of the subjectswith biopsy was taken PanelEIncreased CAGrepeats, more affectof Branaplam, withno mHHT, relativelyno effect oftreatment, asexpected Any coloredpoint, outside ofthe inside dashedlines aresignificant. Red =more, Blue = less It's oral,whileothers areinjected Free!It is the solventused withBranaplam, sousing DMSOalone is thenegative control The relativeabundanceof each typeof splicingerror present Trying to verifythat the systemthe authorspropose isgoing to work There is no impactof HD on celldifferentiation, sothe study will notfocus on themiddle stages ofFigure 1a prevents non-specific Ab bindingas the it coversunoccupied spacethat wouldotherwise attractAbTypically, HDmedications lowerHTT levels to reducemHTT toxicity, butBranaplam did notincrease cell toxicityin fibroblasts andiPSC cells Promote inclusionof exon 7 in theSMN2 transcriptas an interventionfor SMA (spinalmuscular atrophy) PanelsB andCThe increased numberof exons, creates aframeshift, resulting inreduction of mHTT asthe sequence does notcreate poly-Q proteinsequence that isresponsible for HDside effects there are more men thanwomen in the controlgroup (equal inexperimental group)- how close/ far thepeople are from HDthreshold and its effects-ages of the subjectswith biopsy was taken PanelEIncreased CAGrepeats, more affectof Branaplam, withno mHHT, relativelyno effect oftreatment, asexpected Any coloredpoint, outside ofthe inside dashedlines aresignificant. Red =more, Blue = less It's oral,whileothers areinjected Free!It is the solventused withBranaplam, sousing DMSOalone is thenegative control The relativeabundanceof each typeof splicingerror present Trying to verifythat the systemthe authorspropose isgoing to work 

Huntington's Hunt - Call List

(Print) Use this randomly generated list as your call list when playing the game. There is no need to say the BINGO column name. Place some kind of mark (like an X, a checkmark, a dot, tally mark, etc) on each cell as you announce it, to keep track. You can also cut out each item, place them in a bag and pull words from the bag.


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  1. There is no impact of HD on cell differentiation, so the study will not focus on the middle stages of Figure 1a
  2. prevents non-specific Ab binding as the it covers unoccupied space that would otherwise attract Ab
  3. Typically, HD medications lower HTT levels to reduce mHTT toxicity, but Branaplam did not increase cell toxicity in fibroblasts and iPSC cells
  4. Promote inclusion of exon 7 in the SMN2 transcript as an intervention for SMA (spinal muscular atrophy)
  5. Panels B and C
  6. The increased number of exons, creates a frameshift, resulting in reduction of mHTT as the sequence does not create poly-Q protein sequence that is responsible for HD side effects
  7. there are more men than women in the control group (equal in experimental group) - how close/ far the people are from HD threshold and its effects -ages of the subjects with biopsy was taken
  8. Panel E
  9. Increased CAG repeats, more affect of Branaplam, with no mHHT, relatively no effect of treatment, as expected
  10. Any colored point, outside of the inside dashed lines are significant. Red = more, Blue = less
  11. It's oral, while others are injected
  12. Free!
  13. It is the solvent used with Branaplam, so using DMSO alone is the negative control
  15. The relative abundance of each type of splicing error present
  16. Trying to verify that the system the authors propose is going to work